Nimesulide 100mg - Composition,Indications, Dosage, Overdose & More
Nimesulide Tablets is a non-steroidal anti-inflammatory drug that inhibits the Cox-II enzyme that causes pain and inflammation. It reduces the production of free radicals that are produced by neutrophils during inflammation. It also inhibits the synthesis of platelet inhibiting factors, thereby blocking the release of messengers that causes pain and inflammation.
Composition: Active ingredient: Nimesulide
1 single packet of 2 g of granules contains 100 mg of nimesulide. Excipients: macrogol cetostearyl ether, sucrose, maltodextrin, citric acid, orange flavor.
How often can I take nimesulide?
The maximum length of a course of nimesulide therapy is 15 days.
Indications: Treatment of acute pain, primary dysmenorrhea. Nimesil should only be used as a second-line drug. The decision to prescribe nimesulide should be made on the basis of an assessment of all risks for a particular patient.
Contraindications:
• Hypersensitivity to Nimesil, any other NSAID, or to any of the excipients of the drug;
• A history of hyperergic reactions (for example, bronchospasm, rhinitis, urticaria) in connection with the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs;
• History of hepatotoxic reactions to Nimesil; Concomitant use of other substances with potential hepatotoxicity;
• Alcoholism and drug addiction; A history of gastrointestinal bleeding or perforation associated with previous use of NSAIDs;
• Peptic ulcer disease in the acute phase or a history of bleeding in the digestive tract, ulcers, or perforation; Cerebrovascular bleeding or other hemorrhages, as well as diseases accompanied by bleeding;
• Severe bleeding disorders;
• Severe heart failure;
• Severe renal impairment;
• Liver dysfunction;
• Fever and/or flu-like symptoms;
• Age up to 12 years;
• The third trimester of pregnancy and lactation (see section “Use during pregnancy or lactation” and preclinical safety data);
Nimesulide can be taken in various forms, and the oral form may work the best when taken for short durations. It is best to avoid it if you have any serious illnesses that are mentioned above.
Dosage:
In order to reduce the incidence of adverse reactions, it is necessary to use the minimum effective dose for a short time (see Section “Peculiarities of use”). The maximum duration of the course of treatment with Nimesil 100mg is 15 days.
• Adults. 1 packet (100 mg of Nimesil) 2 times a day after meals.
• Elderly patients. Elderly patients do not need to reduce the daily dose (see section “Pharmacokinetics”).
• Children. Medicines containing Nimesil are contraindicated in children under 12 years of age (see also the section “Contraindications”). Given the pharmacokinetic profile in adults and the pharmacodynamic characteristics of nimesulide, dose adjustment for children aged 12 to 18 years is not needed.
Overdose:
Symptoms of acute NSAID overdose are usually limited to the following: apathy, drowsiness, nausea, vomiting, and epigastric pain, which are usually reversible with maintenance therapy. Gastrointestinal bleeding is possible. Rarely possible arterial hypertension, acute renal failure, respiratory depression, and coma. There have been reports of anaphylactoid reactions when using therapeutic doses of NSAIDs, which can occur in case of overdose.
Overdose Treatment :
In case of an overdose of NSAIDs, patients should be provided with symptomatic and supportive treatment. There are no specific antidotes. There is no information on the withdrawal of nimesulide by hemodialysis, but if we take into account its high degree of binding to plasma proteins (up to 97.5%), it is unlikely that dialysis will be effective in overdose. In the presence of symptoms or after a severe overdose within 4 hours after taking the drug, patients can be prescribed vomiting and/or activated charcoal (60-100 g for adults), and/or an osmotic laxative. Forced diuresis, urinary obstruction, hemodialysis, or hemoperfusion may be ineffective due to the high degree of protein binding. Kidney and liver function should be monitored.
How quickly does Nimesulide work?
Nimesulide works rapidly with immediate onset of action when taken orally. It can effectively reduce pain or fever within 15 minutes of taking the medicine. For best results, it should be taken with food or milk to reduce the chances of a stomach upset.
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